Differential olivo-cerebellar cortical control of rebound activity in the cerebellar nuclei

Differential olivo-cerebellar cortical control of rebound activity in the cerebellar nuclei.

The output of the cerebellar cortex is controlled by two main inputs, (i.e., the climbing fiber and mossy fiber-parallel fiber pathway) and activations of these inputs elicit characteristic effects in its Purkinje cells: that is, the so-called complex spikes and simple spikes. Target neurons of the Purkinje cells in the cerebellar nuclei show rebound firing, which has been implicated in the pro...

Editorial: The Olivo-Cerebellar System

Neurophysiology Unit, Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, 2 Brain Connectivity Center, Neurophysiology, IRCCS C. Mondino Neurological Institute, Pavia, Italy, MRC Centre for Developmental Neurobiology, King’s College London, London, UK, Department of Neuroscience, ErasmusMC, Rotterdam, Netherlands, Department of Cerebellar Coordination and Cognition, ...

Contribution of Somatic and Dendritic SK Channels in the Firing Rate of Deep Cerebellar Nuclei: Implication in Cerebellar Ataxia

Introduction: Loss of inhibitory output from Purkinje cells leads to hyperexcitability of the Deep Cerebellar Nuclei (DCN), which results in cerebellar ataxia. Also, inhibition of small-conductancecalcium-activated potassium (SK) channel increases firing rate  f DCN, which could cause cerebellar ataxia. Therefore, SK channel activators can be effective in reducing the symptoms of this disease, ...

Ataxia and the olivo-cerebellar module.

Ataxia is a neurological symptom characterized by abnormal movement, due to cerebellar malfunction. Although the cause of the malfunction varies, from mutations in calcium or potassium channels to progressive degeneration of cerebellar tissue, the neurological symptoms of cerebellar-related ataxia are similar. In this short review we present a model that portrays the olivo-cerebellar system as ...

The cerebellar olivo-corticonuclear connections in the rat.